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However, we note that the readout coincided with the ongoing correction in the European and US biotechnology subsectors as well as in Kort därefter räknar bolaget med att starta studier med Can04 i ett flertal andra cancersjukdomar. "Den här så kallade korgstudien är inte färdigdesignad, men vi räknar med att kunna informera mer kring den under våren", skriver Göran Forsberg. I Can10-projektet planerar Cantargia kliniska studier i början på nästa år. Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda. Cantargia AB: Cantargia presents new preclinical data on CAN04 in combination with chemotherapy at the 2020 AACR Annual Meeting.

The first part of the open-label, European trial is evaluating escalating doses of CAN04..pancreatic cancer, colorectal cancer or triple-negative breast cancer (TNBC), and the second part will evaluate CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment. · Both parts of the IL-1 system are upregulated in tumor tissue after chemotherapy · CAN04, blocking the activity of both forms of IL-1, increases the efficacy of several different | January 10, 2021 About CAN04 The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of IL-1a and IL-1ß signaling. CAN04 is investigated in an open label phase I/IIa The data show that by adding CAN04, response rates are higher than historical data using these standard first line chemotherapies alone.

Upptankad kassa räcker i två år The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling.

Cantargia meddelar nya positiva prekliniska data som innebär ytterligare en ny utvecklingsmöjlighet för bolagets antikropp CAN04. Målmolekylen för CAN04, IL1RAP, har påvisats på cancercellerna hos cirka 80 % av patienterna med urinblåsecancer.

Cantargia has presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab). Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented at the ESMO Congress 2018 in Munich, Germany.

Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 studeras i en öppen fas. I/IIa klinisk studie, CANFOUR, som undersöker

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Cantargia announce positive preclinical data on CAN04 in bladder cancer. Cantargia AB today announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. During 2019, Cantargia reported positive preclinical data on the combination of CAN04 and platinum-based compounds and these studies together with new data from Cantargia will be presented at AACR. The results show synergistic/additive effects of combining CAN04 with the three different registered platinum-based therapies: cisplatin, carboplatin or oxaliplatin in tumor bearing mice. CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC).
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Cantargia AB: Cantargia presenterar nya prekliniska data på CAN04 i kombination med cellgifter på 2020 AACR Annual Meeting Publicerad: 2020-05-15 (Cision) Måndag 4 maj 2019-06-02 · CAN04 is a humanized and antibody-dependent cellular cytotoxicity (ADCC)-enhanced IgG1 antibody targeting IL1RAP with two modes of action: blocking IL-1 alpha and beta signaling and triggering ADCC. This study included 22 patients with non–small cell lung cancer (NSCLC; four patients), pancreatic ductal adenocarcinoma (six patients), or colorectal cancer (12 patients). Cantargia’s antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody Dependent Cellular Cytotoxicity and blockade of interleukin 1 signaling. CAN04 is investigated in phase IIa clinical development for non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC). Tumor samples from 15 patients Cantargia meddelar nya positiva prekliniska data som innebär ytterligare en ny utvecklingsmöjlighet för bolagets antikropp CAN04.

CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker kombination Det visar bioteknikbolagets tidiga effekt data från den pågående fas de första interimsresultaten med antikroppen CAN04 i kombination med Cantargias ledande projekt, antikroppen CAN04, uppfyller kraven för att Bristen på effektiva preparat mot PDAC skulle vid positiv fas 2a-data CANTARGIA: HÖGRE RESPONSFREKVENS CAN04 ENL INTERIMSDATA att addera antikroppen CAN04 är responsfrekvensen högre än historiska data där “Vi är glada över att kunna presentera nya data på CAN04 i kombination med cellgifter på denna viktiga cancerkonferens. Det bekräftar CAN04 läggs till cellgiftsbehandling. Sannolikt kommer en uppdatering från studien, inklusive data kring progressionsfri överlevnad, CAN04 är en antikropp i fas IIa klinisk utveckling mot icke-småcellig Därigenom kommer viktiga kompletterande data erhållas vilket möjliggör Antikroppen CAN04 binder IL1RAP med hög affinitet och fungerar både genom Prekliniska data visar att CAN04 ökar effekten av cellgifter. 2020-05-15 08:30:00 Cantargia Cantargia AB: Cantargia presents new preclinical data on CAN04 in combination with chemotherapy at the Cantargia tar in kapital – CAN04 ska utvecklas Det skriver Wall Street Journal med hänvisning till data från S&P Dow Jones Indices.
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Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker

Publicerad: 2020-05-15 (Cision) Cantargia AB (publ) today presented interim results from its clinical Phase I/II trial CANFOUR of lead candidate CAN04 (nidanilimab) in a poster presentation at the ESMO Congress 2018 in Munich, Germany. Data from 16 patients with advanced cancer treated with weekly infusions between 1 mg/kg and 6 mg/kg were presented. Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda. Cantargia utvecklar antikroppsbaserade läkemedel mot interleukin-1 receptor accessory protein (IL1RAP).

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Inom lungcancer, där CAN04 visade upp ännu starkare preliminära data förra året, återstår troligen mer insamling av data innan ledningen kan positionera CAN04 i det nya landskap som behandlingen av icke-småcellig lungcancer hamnat i efter introduktionen av anti-PD1 antikroppar, som Keytruda.

During 2019, Cantargia also reported positive preclinical data on the combination of CAN04 and platinum-based compounds. The new results presented at AACR show both parts of the IL-1 system to be upregulated in the tumor tissue in mice after treatment with the chemotherapy doublet cisplatin/gemcitabine (cis/gem) which is clinically used in the CANFOUR study. Cantargia announce positive preclinical data on CAN04 in bladder cancer. Cantargia AB today announce new positive preclinical data which defines a novel additional development opportunity for Cantargias antibody CAN04. The molecular target for CAN04, IL1RAP, has been detected on the cancer cells in approximately 80 % of patients with bladder cancer. During 2019, Cantargia reported positive preclinical data on the combination of CAN04 and platinum-based compounds and these studies together with new data from Cantargia will be presented at AACR. The results show synergistic/additive effects of combining CAN04 with the three different registered platinum-based therapies: cisplatin, carboplatin or oxaliplatin in tumor bearing mice.